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"Blood cells always looked so beautiful to me," he says.

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' then I sat down and we began to chart the family." Cawein remembers the pain that showed on the Ritchie brother's and sister's faces. Methemoglobin which is blue, is a nonfunctional form of the red hemoglobin that carries oxygen.

"They were really embarrassed about being blue," he said. It is the color of oxygen-depleted blood seen in the blue veins just below the skin.

Cawein drew "lots of blood" from the Ritchies and hurried back to his lab.

He tested first for abnormal hemoglobin, but the results were negative.

"Her face and her fingernails were almost indigo blue. She told me that her family was the blue Combses who lived up on Ball Creek.

She was a sister to one of the Fugate women." About this same time, another of the blue Combses, named Luke, had taken his sick wife up to the clinic at .

Most lived to their 80s and 90s without serious illness associated with the skin discoloration.

For some, though, there was a pain not seen in lab tests.

"She had been out in the cold and she was just blue!

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